Pam I'm not a doctor, so please take this for what it's worth. I've taken MTX for the last 2 + years, and I've been told by my Rheumy to stop taking MTX ,if I am on an antibiotic, and or running a fever.
And that's what I usually do, however if I'm not on antibiotics but can't seem to shake a chronic cold , I'll skip a week or so of MTX without consulting anyone, just so my body can get back to "normal"(whatever that is for "us" ) Doesn't happen very often.
If you still feel nervous about not taking the MTX , call your Pharamacist tomorrow (one day or even two days later is not going to matter)and ask his opinon, or wait til Mon. and call or pcp.
hope this helps,